Pseudouridine: What is it and Why Should you Care?
The Nobel Prize in Physiology or Medicine was awarded for discovering use of Pseudouridine to suppress immune responses to synthetic mRNA, and use of that discovery in COVID-19 mRNA vaccines.
Uridine, one of the four key components of natural RNA and mRNA (A, U, G, C), shown together with the structures of Pseudouridine and N1-methyl-Pseudouridine
Natural RNA, including mRNA, consists of a polymerized string of four different compounds - A, U, G, C. U = Uridine. There are many different natural forms of RNA in cells, but in genera…